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Genetic epidemiology of multistage carcinogenesis

โœ Scribed by Kari Hemminki; Pertti Mutanen


Book ID
114070319
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
118 KB
Volume
473
Category
Article
ISSN
0027-5107

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## Abstract We consider the implications of multistage carcinogenesis for the incidence of cancer in human populations. When clonal expansion of partially altered cells is properly accounted for, we find it unnecessary to invoke genomic instability as an early event in malignant transformation. Env