Genetic control of serum alkaline phosphatase in the chicken

✍ Scribed by Wilcox, F. H.

• Publisher: John Wiley and Sons
• Year: 1963
• Tongue: English
• Weight: 780 KB
• Volume: 152
• Category: Article
• ISSN: 0022-104X
• DOI: 10.1002/jez.1401520208

✦ Synopsis

There is ample evidence of genetic differences in the level of alkaline phosphatase in blood serum or plasma. Differences have been described between strains of rats (Tuba, '53), and breeds of cattle Kunkel et al., '53; Rusoff et al., '54) and swine (Combs et al., '59). Hypophosphatasia in humans has been suggested to have a genetic basis, possibly by way of an autosomal recessive gene (Fraser, '57).

Recently it has been shown with chickens that inbred lines (Stutts et al., '57) as well as sire-and dam-families of the same strain (Matsumoto et al., '60) differ in the level of this enzyme in their sera.

This investigation was conducted to find out if a line high in serum alkaline phosphatase could be developed by selective breeding, and to gain further evidence on the genetics of the trait by crossing the high line to a random bred control. A major consideration has been the physiological basis of high level in the serum of the high line. This enzyme was chosen because there is evidence that its level is related positively to egg production (Gotowska et al., '43). ~ 1 Scientific article no. A940; Contribution no. 3298 of the Maryland Agricultural Expenment Statlon. This investigation was supported in part by a research grant (RG-6507) from the Division of General Medical Sciences, Public Health Service. 195 Line Fresh Control Serum (mM nitrophenol/l/hr)' Kidney (mM nitrophenol/kg/hr)t Control