𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Genetic control of oncogenesis by murine sarcoma virus moloney pseudotype. I. Genetics of resistance in AKR mice

✍ Scribed by A. Colombatti; D. Collavo; G. Biasi; L. Chieco-Bianchi

Publisher
John Wiley and Sons
Year
1975
Tongue
French
Weight
504 KB
Volume
16
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Injection of Moloney mouse sarcoma virus (M‐MSV) in adult mice of several inbred strains revealed that all strains except AKR are highly susceptible to M‐MSV tumor development. F1 hybrids between AKR and CBA, DBA/2 or NIH mice are as resistant (93%) as the parental AKR strain, which indicates that resistance is transmitted as a dominant character. First backcross mice to the susceptible parent show a 3:1 ratio of resistant to susceptible mice. This is the expected ratio for two segregating loci which independently confer resistance. The incidence of resistant F2 mice is somewhat lower than expected. Further support for the two‐gene hypothesis was obtained in second backcross mice. None of the major genes affecting MuLV infection (Fv‐2 and H‐2) seems to play any role in this system and no linkage was found with Thy. 1 and albino, dilute, agouti and brown markers.

📜 SIMILAR VOLUMES

Genetic control of oncogenesis by murine
Genetic control of oncogenesis by murine sarcoma virus moloney pseudotype. II. A dominant epistatic susceptibility gene
✍ A. Colombatti; D. Collavo; G. Biasi; L. Chieco-Bianchi 📂 Article 📅 1975 🏛 John Wiley and Sons 🌐 French ⚖ 454 KB

## Abstract We have shown in the preceding paper that AKR mice are highly resistant to M‐MSV tumor development, and that resistance is transmitted as a dominant character In the present studies the tumor‐response pattern of F1 hybrids between resistant AKR and susceptible strains (C57Bl/6, BALB/c a

Enhancement by asbestos of oncogenesis b
Enhancement by asbestos of oncogenesis by moloney murine sarcoma virus in CBA mice
✍ Kyotaro Kanazawa; Tadashi Yamamoto; Yasuhito Yuasa 📂 Article 📅 1979 🏛 John Wiley and Sons 🌐 French ⚖ 924 KB

## Abstract Five μg of finely ground crocidolite asbestos (UICC standard sample) were Injected intraper‐ itoneally into 3‐week‐old CBA mice, together with 10^5^ FFU of Moloney murine sarcoma virus. Altogether 44 out of 61 mice (72.1%) so treated developed palpable intraperitoneal tumours, and half

Genetic control of sensitivity to molone
Genetic control of sensitivity to moloney-virus-induced leukemias in mice. I. Demonstration of multigenic control
✍ S. Gisselbrecht; F. Pozo; P. Debré; M. A. Hurot; M. J. Lacombe; J. P. Levy 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 French ⚖ 838 KB

## Abstract The appearance of hematopoietic malignancies and the level of viremia were studied in mice of different inbred strains and their F~1~ or F~2~ hybrids inoculated with the Moloney leukemia virus (MLV) The viremia was regularly measured in individual mice by radioimmunoassay of the major i

Genetics of murine sarcoma virus (msv)—i
Genetics of murine sarcoma virus (msv)—induced tumors in akr mice: Evidence that late progressing and early regressing tumors are controlled by different genes
✍ A. Colombatti; L. Chieco-Bianchi; A. De Rossi; E. D'andrea; D. Collavo 📂 Article 📅 1977 🏛 John Wiley and Sons 🌐 French ⚖ 878 KB

The genetics of late appearing MSV tumors showing a progressive growth pattern i n AKR mice was investigated. The late MSV tumor response in F, hybrids depended on the genetic background of the non-AKR parent. Within the 4-month observation period following virus injection, (CBA x AKR)F,, (DBA/ZxAKR