Genetic control of oncogenesis by murine sarcoma virus moloney pseudotype. II. A dominant epistatic susceptibility gene

✍ Scribed by A. Colombatti; D. Collavo; G. Biasi; L. Chieco-Bianchi

• Publisher: John Wiley and Sons
• Year: 1975
• Tongue: French
• Weight: 454 KB
• Volume: 16
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910160310

✦ Synopsis

Abstract

We have shown in the preceding paper that AKR mice are highly resistant to M‐MSV tumor development, and that resistance is transmitted as a dominant character In the present studies the tumor‐response pattern of F1 hybrids between resistant AKR and susceptible strains (C57Bl/6, BALB/c and BIOBR) following injection with Moloney mouse sarcoma virus (M‐MSV) resembles that of the non‐AKR parent. Segregation is observed in first backcross (Bcl) and F2 mice, and the segregation ratios up to Bc3 mice fit a one‐gene model. The data of triple cross hybrids suggests that this dominant susceptibility gene inhibits the phenotypic expression of M‐MSV tumor resistance in some susceptible Fv‐1^bb^ strains as well as in their hybrids with AKR. Neither Fv‐1 nor H‐2 exerts any significant influence on this complex system.