The genome of the BALB/c mouse strain provides alleles that dominantly inhibit hepatocellular tumor development in F1 crosses with the highly hepatocarcinogenesis-susceptible C3H/He strain. Genome-wide linkage analysis using a 1536 -single-nucleotide polymorphism array in a (C3H/He Ψ BALB/c)F2 inter
Genetic Control by the hr-Locus of Susceptibility and Resistance to Leukemia
β Scribed by H. Meier, D. D. Myers and R. J. Huebner
- Book ID
- 123649088
- Publisher
- National Academy of Sciences
- Year
- 1969
- Tongue
- English
- Weight
- 987 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0027-8424
- DOI
- 10.2307/59414
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## Abstract Genetic control of splenomegaly which occurs at a late stage of Friend leukemia virus infection was studied in hybrid mice between DDDβFv^r^ and C57BL/6. It was demonstrated that this late splenomegaly was mainly controlled by a single autosomal locus with the dominant allele for resist