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Genetic association studies between dementia of the Alzheimer's type and three receptors for apolipoprotein E in a Caucasian population

✍ Scribed by Corinne L Lendon; Christopher J. Talbot; Nick J Craddock; Sang Woo Han; Michelle Wragg; John C Morris; Alison M Goate


Book ID
117476110
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
76 KB
Volume
222
Category
Article
ISSN
0304-3940

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A common polymorphism in the Ξ±1-antichymotrypsin (ACT) gene has been found to modify the APOE\*4-associated risk of Alzheimer's disease due to an apparent interaction between the two loci. This study was undertaken to determine the gender-and age-related distributions of these two polymorphisms in t