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Genetic association between Alzheimer's disease and the low density lipoprotein receptor-related protein gene in the French population

✍ Scribed by Patrice Verpillat; Sandrine Bouley; Didier Hannequin; Serge Belliard; Michele Puel; Dominique Campion; Francoise Clerget-Darpoux; Alexis Brice


Book ID
117411661
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
183 KB
Volume
21
Category
Article
ISSN
0197-4580

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## Abstract A number of studies suggest that brain cholesterol metabolism may play a role in Alzheimer's disease (AD) development, probably through modulation of amyloid beta production. The discovery that apolipoprotein E (__APOE__) Ξ΅4 allele is a risk factor for sporadic AD raises the possibility