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Genetic association studies between Alzheimer's disease and two polymorphisms in the low density lipoprotein receptor-related protein gene

✍ Scribed by M.Ilyas Kamboh; Robert E Ferrell; Steven T DeKosky

Book ID: 117476562
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 50 KB
Volume: 244
Category: Article
ISSN: 0304-3940
DOI: 10.1016/s0304-3940(98)00141-4

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## Abstract A number of studies suggest that brain cholesterol metabolism may play a role in Alzheimer's disease (AD) development, probably through modulation of amyloid beta production. The discovery that apolipoprotein E (__APOE__) ε4 allele is a risk factor for sporadic AD raises the possibility