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Genetic aspects of ankylosing spondylitis

✍ Scribed by Muhammad A. Khan; Edward J. Ball

Book ID
114464721
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
321 KB
Volume
16
Category
Article
ISSN
1521-6942

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It has long been known that the major histocompatibility complex (MHC) is essentially involved in genetic susceptibility to ankylosing spondylitis (AS). The HLA-B27 antigen has been accounted for 20 to 50% of the total genetic risk for this disease. However, susceptibility to AS cannot be fully expl

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## Abstract ## Objective To define the genetic basis of susceptibility to ankylosing spondylitis (AS), especially non–major histocompatibility complex (MHC) genes. ## Methods The study group comprised 244 affected sibling pairs from 180 pedigrees of primarily European ancestry. Sibling pairs wer