## Abstract Nonrandom allelic loss on chromosome 3p is a common event in nasopharyngeal carcinoma (NPC) with the implication that certain tumor suppressor gene(s) in this region are involved in the pathogenesis of these tumors. The __BLU__ gene, located at 3p21.3, has recently been identified as a
Genetic and Epigenetic Alterations of DLC-1, a Candidate Tumor Suppressor Gene, in Nasopharyngeal Carcinoma
β Scribed by Dan PENG; Cai-Ping REN; Hong-Mei YI; Liang ZHOU; Xu-Yu YANG; Hui LI; Kai-Tai YAO
- Book ID
- 111357677
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 545 KB
- Volume
- 38
- Category
- Article
- ISSN
- 1672-9145
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## Abstract Nasopharyngeal carcinoma (NPC) is a rare malignancy with unique genetic, viral and environmental characteristic that distinguishes it from other head and neck carcinomas. The clinical management of NPC remains challenging largely due to the lack of early detection strategies for this tu
## Abstract Allelic imbalance (AI) on chromosome arm 22q has been detected in 20%β40% of colorectal cancers, suggesting that this chromosome arm has a tumorβsuppressor gene involved in colorectal carcinogenesis. Recently, we isolated a candidate tumorβsuppressor gene, __MYO18B__, at 22q12.1, that i