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Genetic and epigenetic alterations as hallmarks of the intricate road to cancer

✍ Scribed by Macaluso, Marcella; Paggi, Marco G; Giordano, Antonio

Book ID
110068041
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
129 KB
Volume
22
Category
Article
ISSN
0950-9232

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## Abstract Allelic imbalance (AI) on chromosome arm 22q has been detected in 20%–40% of colorectal cancers, suggesting that this chromosome arm has a tumor‐suppressor gene involved in colorectal carcinogenesis. Recently, we isolated a candidate tumor‐suppressor gene, __MYO18B__, at 22q12.1, that i