Genes with triplet repeats: candidate mediators of neuropsychiatric disorders
โ Scribed by Christopher A. Ross; Melvin G. McInnis; Russell L. Margolis; Shi-Hua Li
- Book ID
- 118391453
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 923 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0166-2236
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The expansion of trinucleotide repeats has been associated with late-onset neurodegenerative disorders. Although the genes harbouring the triplet expansions may be widely expressed, the pathological expression of these diseases is restricted to specific tissues. Non-insulin-dependent diabetes mellit
A group of diseases are due to abnormal expansions of trinucleotide repeats. These diseases all affect the nervous system. In addition, they manifest the phenomenon of anticipation, in which the disease tends to present at an earlier age or with greater severity in successive generations. Many addit