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Analysis of thirteen trinucleotide repeat loci as candidate genes for schizophrenia and bipolar affective disorder

✍ Scribed by Jain, Sanjeev; Leggo, Jayne; DeLisi, Lynne E.; Crow, Timothy J.; Margolis, Russell L.; Li, Shi-Hua; Goodburn, Sandy; Walsh, Cathy; Paykel, Eugene S.; Ferguson-Smith, Malcolm A.; Ross, Christopher A.; Rubinsztein, David C.

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
49 KB
Volume
67
Category
Article
ISSN
0148-7299
DOI
10.1002/(sici)1096-8628(19960409)67:2<139::aid-ajmg3>3.0.co;2-n

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✦ Synopsis

A group of diseases are due to abnormal expansions of trinucleotide repeats. These diseases all affect the nervous system. In addition, they manifest the phenomenon of anticipation, in which the disease tends to present at an earlier age or with greater severity in successive generations. Many additional genes with trinucleotide repeats are believed to be expressed in the human brain, As anticipation has been reported in schizophrenia and bipolar affective disorder, w e have examined allele distributions of 13 trinueleotide repeat-containing genes, many novel and all expressed in the brain, in genomic DNA from schizophrenic (n = 20-97) and bipolar affective disorder patients (23-30) and controls (n = 43-146). No evidence was obtained to implicate expanded alleles in these 13 genes as causal factors in these diseases. @ I

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