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Generation of the NUP98-TOP1 fusion transcript by the t(11;20) (p15;q11) in a case of acute monocytic leukemia

✍ Scribed by Suning Chen; Yongquan Xue; Zhong Chen; Yu Guo; Yafang Wu; Jinlan Pan

Book ID
114135447
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
118 KB
Volume
140
Category
Article
ISSN
0165-4608

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Expression of NUP98/TOP1, but not of TOP
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The t(11;20)(p15;q11) is a rare but recurrent translocation that so far has been described in only four acute myeloid leukemias (AMLs), two treatment-related myelodysplastic syndromes (t-MDSs), and one case of polycythemia vera. Recently, the t(11;20) was shown to result in a fusion of the NUP98 and

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## Abstract The __NUP98__ gene at 11p15 is known to be fused to __DDX10, HOXA9, HOXA11, HOXA13, HOXD11, HOXD13, LEDGF__, __NSD1, NSD3, PMX1__, __RAP1GDS1__, and __TOP1__ in various hematologic malignancies. The common theme in all __NUP98__ chimeras is a transcript consisting of the 5β€² part of __NU

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