Expression of the novel NUP98/PSIP1 fusion transcripts in myelodysplastic syndrome with t(9;11)(p22;p15)
β Scribed by Katsuya Yamamoto; Yuji Nakamachi; Kimikazu Yakushijin; Yohei Funakoshi; Atsuo Okamura; Seiji Kawano; Hiroshi Matsuoka; Hironobu Minami
- Book ID
- 114795656
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 531 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0902-4441
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The t(11;20)(p15;q11) is a rare but recurrent translocation that so far has been described in only four acute myeloid leukemias (AMLs), two treatment-related myelodysplastic syndromes (t-MDSs), and one case of polycythemia vera. Recently, the t(11;20) was shown to result in a fusion of the NUP98 and
The nucleoporin gene NUP98 has been reported to be fused to 9 partner genes in hematologic malignancies with 11p15 translocations. The NUP98-HOXA9 fusion gene has been identified in acute myeloid leukemia (AML) and chronic myelogenous leukemia with t(7;11)(p15;p15). We report here a novel NUP98 part