The nucleoporin gene NUP98 has been reported to be fused to 9 partner genes in hematologic malignancies with 11p15 translocations. The NUP98-HOXA9 fusion gene has been identified in acute myeloid leukemia (AML) and chronic myelogenous leukemia with t(7;11)(p15;p15). We report here a novel NUP98 part
Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia
β Scribed by Nakamura, Takuro; Largaespada, David A.; Lee, Maxwell P.; Johnson, Laura A.; Ohyashiki, Kazuma; Toyama, Keisuke; Chen, Sai Juan; Willman, Cheryl L.; Chen, I-Ming; Feinberg, Andrew P
- Book ID
- 109915197
- Publisher
- Nature Publishing Group
- Year
- 1996
- Tongue
- English
- Weight
- 548 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1061-4036
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## Abstract The __NUP98__ gene at 11p15 is known to be fused to __DDX10, HOXA9, HOXA11, HOXA13, HOXD11, HOXD13, LEDGF__, __NSD1, NSD3, PMX1__, __RAP1GDS1__, and __TOP1__ in various hematologic malignancies. The common theme in all __NUP98__ chimeras is a transcript consisting of the 5β² part of __NU
## Abstract The chimeric gene __NUP98/HOXC13__ was detected in a patient with a de novo acute myeloid leukemia and a t(11;12)(p15;q13). Fluorescence in situ hybridization with PAC1173K1 identified the breakpoint on 11p15, indicating that the __NUP98__ gene was involved in the translocation. At 12q1