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Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia

✍ Scribed by Nakamura, Takuro; Largaespada, David A.; Lee, Maxwell P.; Johnson, Laura A.; Ohyashiki, Kazuma; Toyama, Keisuke; Chen, Sai Juan; Willman, Cheryl L.; Chen, I-Ming; Feinberg, Andrew P


Book ID
109915197
Publisher
Nature Publishing Group
Year
1996
Tongue
English
Weight
548 KB
Volume
12
Category
Article
ISSN
1061-4036

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The chromosome translocation t(7;11)(p15
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The nucleoporin gene NUP98 has been reported to be fused to 9 partner genes in hematologic malignancies with 11p15 translocations. The NUP98-HOXA9 fusion gene has been identified in acute myeloid leukemia (AML) and chronic myelogenous leukemia with t(7;11)(p15;p15). We report here a novel NUP98 part

Fusion of the NUP98 gene and the homeobo
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## Abstract The __NUP98__ gene at 11p15 is known to be fused to __DDX10, HOXA9, HOXA11, HOXA13, HOXD11, HOXD13, LEDGF__, __NSD1, NSD3, PMX1__, __RAP1GDS1__, and __TOP1__ in various hematologic malignancies. The common theme in all __NUP98__ chimeras is a transcript consisting of the 5β€² part of __NU

Human homeobox gene HOXC13 is the partne
✍ Roberta La Starza; Maurizio Trubia; Barbara Crescenzi; Caterina Matteucci; Massi πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 123 KB πŸ‘ 1 views

## Abstract The chimeric gene __NUP98/HOXC13__ was detected in a patient with a de novo acute myeloid leukemia and a t(11;12)(p15;q13). Fluorescence in situ hybridization with PAC1173K1 identified the breakpoint on 11p15, indicating that the __NUP98__ gene was involved in the translocation. At 12q1