Generation and Trapping of 4-Methylene-5-(bromomethylene)-4,5-dihydrothiazole with Dienophiles
✍ Scribed by Al Hariri, Mouaffak; Jouve, Karine; Pautet, Félix; Domard, Monique; Fenet, Bernard; Fillion, Houda
- Book ID
- 120080816
- Publisher
- American Chemical Society
- Year
- 1997
- Tongue
- English
- Weight
- 377 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0022-3263
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Treatment of 4,5-bis(dibromomethyl)thiazole (1a) with of the cycloadditions between 2a and naphthoquinones 6 agrees with the predictions of the frontier molecular orbital sodium iodide in DMF led to 4,5-bis(bromomethylene)-4,5dihydrothiazole (2a). Trapping the latter in situ with theory. In contrast
4,5-Dihydro-2-methyloxazole la and 4,5-dihydro-2,4.4-trimethyloxazole lb, which are examples of cyclic imidate esters, undergo 1,fdipolar cycloaddition reactions with benzonitrile N-oxide, to give the appropriate 5,6-dihydro-7a-methyl-3-