1,3-dipolar cycloaddition reactions of nitrile oxides with 4,5-dihydrooxazole and 4,5-dihydrothiazole derivatives
โ Scribed by David J. Miller; Richard M. Scrowston; Peter D. Kennewell; Robert Westwood
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- French
- Weight
- 659 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0040-4020
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โฆ Synopsis
4,5-Dihydro-2-methyloxazole la and 4,5-dihydro-2,4.4-trimethyloxazole lb, which are examples of cyclic imidate esters, undergo 1,fdipolar cycloaddition reactions with benzonitrile N-oxide, to give the appropriate 5,6-dihydro-7a-methyl-3-
๐ SIMILAR VOLUMES
Dihydro-1H-imidazole 3-oxides bearing different substituents at positions 1 and 2 of the heterocycle were shown to react with a wide range of acceptor-substituted alkynes forming corrsponding cycloadductsderivatives of 1,2,3,7a-tetrahydroimidazo[1,2-b]isoxazole. High regioselectivity of this process
The influence of solvents and different structural factors on the rate of 1,3-dipolar cycloaddition reaction of the 4,5-dihydro-1H-imidazole 3-oxide derivatives with alkynes have been studied. Nitrones and alkynes have been ranged by their relative activity in this reaction. Using the DFT calculatio