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Generation and molecular analyses of two rheumatoid synovial fluid–derived IgG rheumatoid factors

✍ Scribed by Edward W. Lu; Michael Deftos; Tsaiwei Olee; De-Feng Huang; Rafael W. Soto-Gil; Dennis A. Carson; Pojen P. Chen

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
971 KB
Volume
36
Category
Article
ISSN
0004-3591

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✦ Synopsis

To study the Ig genes that encode IgG rheumatoid factor (IgG-RF) from rheumatoid synovial fluid.

Methods. We used rheumatoid synovial fluid B cells to generate IgG-RF-secreting hybridomas. We then characterized their binding properties and determined their nucleotide sequences.

Results. Two monospecific IgG-RFs were ob-

From the

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