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Quantitation of cells secreting rheumatoid factor of igg, iga, and igm class after elution from rheumatoid synovial tissue

✍ Scribed by Torstein Egeland; Tor Lea; George Saari; Ove J. Mellbye; Jacob B. Natvig

Publisher: John Wiley and Sons
Year: 1982
Tongue: English
Weight: 595 KB
Volume: 25
Category: Article
ISSN: 0004-3591
DOI: 10.1002/art.1780251210

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

In an indirect hemolytic plaque assay that used sheep erythrocytes coated with normal rabbit IgG or reduced/alkylated IgG anti–sheep erythrocytes, mononuclear cells eluted from rheumatoid synovial tissue of 7 of 11 patients with seropositive rheumatoid arthritis contained cells that secreted rheumatoid factor of IgG, IgA, and IgM classes. The number of rheumatoid factor–secreting cells varied from <1% to 53% of the total number of eluted immunoglobulin‐secreting cells. In contrast, immunoglobulin‐secreting cells and rheumatoid factor–secreting cells were scanty in blood compared with synovial tissue mononuclear cells.

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