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General synthesis of chiral β-hydroxy sulfones via enantioselective ruthenium-catalyzed hydrogenation

✍ Scribed by P Bertus; P Phansavath; V Ratovelomanana-Vidal; J.-P Genêt; A.R Touati; T Homri; B.Ben Hassine

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
225 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis

A new ruthenium-promoted hydrogenation of fl-keto sulfones using MeO-BIPHEP as ligand is reported with complete conversions and enantiomeric excesses over 95%.

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General Enantioselective Synthesis of Butyrolactone Natural Products via Ruthenium-SYNPHOS®-Catalyzed Hydrogenation Reactions
✍ Delphine Blanc; Jonathan Madec; Florence Popowyck; Tahar Ayad; Phannarath Phansa 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 154 KB 👁 1 views

## Abstract Enantioselective syntheses of several paraconic acids have been achieved using catalyzed asymmetric hydrogenation of β‐keto esters with SYNPHOS^®^ as a ligand. This strategy allowed the short synthesis of biologically active (−)‐methylenolactocin **1**, (−)‐protolichesterinic acid **2**