General Preparation of Functionalized o-Nitroarylmagnesium Halides through an Iodine–Magnesium Exchange
✍ Scribed by Ioannis Sapountzis; Paul Knochel
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 70 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0044-8249
No coin nor oath required. For personal study only.
✦ Synopsis
We thank the Deutsche Forschungsgemeinschaft (Leibniz program) for financial support. I.S. thanks Aventis Pharma (Frankfurt a.M.) for a fellowship. We also thank Chemetall GmbH (Frankfurt a.M.) and BASF AG (Ludwigshafen) for generous gifts of chemicals.
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At -40°C aryl iodides that contain other functional groups can be selectively converted into Grignard reagents, which react with electrophiles such as benzaldehyde in the usual manner [Eq. (a)]. Aryl bromides and iodides that are immobilized as esters on a Wang resin behave analogously.