General approach for the calculation of tissue to plasma partition coefficients
β Scribed by Walter Schmitt
- Book ID
- 116919721
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 221 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0887-2333
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Tissue:plasma (P(t:p)) partition coefficients (PCs) are important parameters describing tissue distribution of drugs. The ultimate goal in early drug discovery is to develop and validate in silico methods for predicting a priori the P(t:p) for each new drug candidate. In this context, tissue composi
A Computer Automated Structure Evaluation (CASE j approach to the calculation of partition coefficient (log P ) has been developed. A linear regression equation was obtained linking the log P value of molecules to some of their fragments as identified by a CASE analysis. The relationship was obtaine