Potential errors associated with the in vivo estimation of tissue to plasma partition coefficients
β Scribed by P. Ballard; D.E. Leahy; M. Rowland
- Book ID
- 117628675
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 142 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0928-0987
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Age-related changes in tissue distribution characteristics of cefazolin, a cephalosporin antibiotic, were examined for nonelirninating organs of rats. The in vivo tissue-to-plasma partition coefficients ( ~, v , v o ) varied markedly among different ages and organs. In particular, muscle and skiti a
The tissue:plasma (P t:p ) partition coefficients (PCs) are important drugspecific input parameters in physiologically based pharmacokinetic (PBPK) models used to estimate the disposition of drugs in biota. Until now the use of PBPK models in early stages of the drug discovery process was not possib