𝔖 Bobbio Scriptorium
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Gene therapy with E2F-1 induces apoptosis in gliomas

Book ID
120874967
Publisher
Adis International Limited (now part of Wolters Kluwer Health)
Year
1998
Weight
163 KB
Volume
&NA;
Category
Article
ISSN
1173-8324

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## BACKGROUND. E2F-1 is a transcription factor that stimulates cellular proliferation and cell cycle progression from G 1 to S-phase. Somewhat paradoxically, E2F-1 also has the properties of a tumor suppressor. Overexpression of E2F-1 has been shown to induce apoptosis in some cancer cells. In the