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Gene expression profiling of E2F-1-induced apoptosis

✍ Scribed by Azemat Jamshidi-Parsian; Yanbin Dong; Xinyu Zheng; Heshan Sam Zhou; Wolfgang Zacharias; Kelly M. McMasters

Book ID: 116506923
Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 598 KB
Volume: 344
Category: Article
ISSN: 0378-1119
DOI: 10.1016/j.gene.2004.09.030

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## BACKGROUND. E2F-1 is a transcription factor that stimulates cellular proliferation and cell cycle progression from G 1 to S-phase. Somewhat paradoxically, E2F-1 also has the properties of a tumor suppressor. Overexpression of E2F-1 has been shown to induce apoptosis in some cancer cells. In the