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E2F-1 induced apoptosis

✍ Scribed by A.C. Phillips; K.H. Vousden

Book ID
110300086
Publisher
Springer
Year
2001
Tongue
English
Weight
339 KB
Volume
6
Category
Article
ISSN
1360-8185

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## BACKGROUND. E2F-1 is a transcription factor that stimulates cellular proliferation and cell cycle progression from G 1 to S-phase. Somewhat paradoxically, E2F-1 also has the properties of a tumor suppressor. Overexpression of E2F-1 has been shown to induce apoptosis in some cancer cells. In the