Gene therapy of hepatoma: bystander effects and non-apoptotic cell death induced by thymidine kinase and ganciclovir
β Scribed by Yoshiyasu Kaneko; Ayumi Tsukamoto
- Book ID
- 116123324
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 828 KB
- Volume
- 96
- Category
- Article
- ISSN
- 0304-3835
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## Abstract ## Purpose To study the characteristics of diffusion magnetic resonance imaging (MRI) contrast in a rat brain BT4C glioma during progression of ganciclovir (GCV)βthymidine kinase gene therapyβinduced programmed cell death (PCD) in vivo. ## Materials and Methods The trace of the diffu
## Abstract We previously showed that gap junction intercellular communication mediates the bystander effect in anticancer gene therapy with the herpes simplex virus thymidine kinase (HSVβtk) and ganciclovir. Because most cancer cell lines have lost their ability to communicate through gap junction