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Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells

✍ Scribed by Fischer, Ute; Steffens, Sabine; Frank, Susanne; Rainov, Nikolai G; Schulze-Osthoff, Klaus; Kramm, Christof M


Book ID
110069352
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
596 KB
Volume
24
Category
Article
ISSN
0950-9232

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## Abstract ## Purpose To study the characteristics of diffusion magnetic resonance imaging (MRI) contrast in a rat brain BT4C glioma during progression of ganciclovir (GCV)‐thymidine kinase gene therapy‐induced programmed cell death (PCD) in vivo. ## Materials and Methods The trace of the diffu