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Gene therapy of hepatoma by intratumoral injection with thymidine kinase gene and ganciclovir administration

✍ Scribed by Yoshiyasu Kaneko; Ayumi Tsukamoto

Book ID: 113401745
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 393 KB
Volume: 4
Category: Article
ISSN: 0928-4346
DOI: 10.1016/0928-4346(95)00261-8

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## Abstract We have earlier demonstrated that inhibition of polyamine biosynthesis with difluoromethylornithine (DFMO) can be used to enhance the cytotoxicity of herpes simplex virus thymidine kinase/ganciclovir (HSV‐TK/GCV) gene therapy in different tumor cell lines. Here, the utility of this trea