Gene Therapy and Cell Therapy Through the Liver: Current Aspects and Future Prospects

✍ Scribed by Shuji Terai, Takeshi Suda (eds.)

• Publisher: Springer Japan
• Year: 2016
• Tongue: English
• Leaves: 183
• Edition: 1
• Category: Library

✦ Synopsis

This book reports the recent progress in gene and cell therapy through the liver and aims to facilitate a comprehensive understanding of the current aspects and future prospects from basic research to clinical therapies. Edited by pioneering researchers, this volume presents extensive information to principal investigators, researchers, postdocs and clinicians for examining the wide varieties of pathological conditions both inside and outside the liver.

Providing not only the basic and clinical aspects of therapy, this volume is special in that it focuses on the administrative and regulatory difficulties of actual clinical application and legal regulations in different parts of the globe. By indicating the advantages and limitations of the most promising gene and cell therapies targeting the liver, this book will inspire readers to develop a feasible treatment in the next generation.

✦ Table of Contents

Front Matter....Pages i-x
Liver-Targeted Gene and Cell Therapies: An Overview....Pages 1-11
Front Matter....Pages 13-13
Macrophage Therapy for Liver Fibrosis and Regeneration....Pages 15-23
Liver Regeneration Therapy Using Autologous Bone Marrow-Derived Cells for Cirrhotic Patients....Pages 25-34
Novel Immunotherapy Using Liver-Derived Natural Killer Cells for Preventing Hepatocellular Carcinoma Recurrence in Liver Transplantation....Pages 35-45
Cell-Based Immunotherapy for HCC: Our Experiences and Future Directions....Pages 47-55
Front Matter....Pages 57-57
AAV Vector-Mediated Liver Gene Therapy and Its Implementation for Hemophilia....Pages 59-73
Potential Usage of Human Artificial Chromosome for Regenerative Medicine....Pages 75-83
Image-Guided Hydrodynamic Gene Delivery to the Liver: Toward Clinical Applications....Pages 85-92
Front Matter....Pages 93-93
The Way to Clinical Application of Human Pluripotent Stem Cells....Pages 95-103
Regulation for Gene and Cell Therapy Medicinal Products in Europe....Pages 105-123
iPSC-Derived Products: Current Regulations....Pages 125-137
Critical Path Initiative for Regenerative Medicine in Japan....Pages 139-146
Front Matter....Pages 147-147
Aseptic Manufacturing of Regenerative Medicine Products Using Isolator Technology....Pages 149-170
Cell and Vector Production Facility for Gene Therapy and Cell Therapy....Pages 171-185

✦ Subjects

Hepatology; Gene Therapy; Gastroenterology; Regenerative Medicine/Tissue Engineering; Internal Medicine