Human Gene Therapy: Current Opportunities and Future Trends

✍ Scribed by G. J. Nabel (auth.), Gabor M. Rubanyi, Seppo Ylä-Herttuala (eds.)

Publisher: Springer-Verlag Berlin Heidelberg
Year: 2003
Tongue: English
Leaves: 261
Series: Ernst Schering Research Foundation Workshop 43
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

Advances in genetics, molecular biology and gene delivery technologies in recent years have lead to new gene therapy strategies to treat a variety of diseases. This book gives a comprehensive overview of the present status and future directions of gene delivery systems and therapeutic strategies for the clinical application of gene therapy in cancer, cardiovascular and central nervous system diseases. Stem cell-based therapies and gene expression regulatory systems, as novel platform technologies for various gene therapy applications are also discussed. Leading experts give excellent overviews of basic molecular aspects and clinical applications in this new emerging biomedical field.

✦ Table of Contents

Front Matter....Pages I-XV
The Future of Gene Therapy....Pages 1-16
Front Matter....Pages 17-17
Angiogenesis Clinical Trials....Pages 19-23
AAV Vectors, the Future Workhorse of Human Gene Therapy....Pages 25-40
Nonviral Vectors for Cardiovascular Gene Delivery....Pages 41-59
Gene Therapy for Coronary Artery Disease: Preclinical and Initial Clinical Results with Intracoronary Administration of Ad5FGF-4....Pages 61-78
Front Matter....Pages 79-79
Cancer Gene Therapy: Present Status and Future Directions....Pages 81-88
Oncolytic Virotherapy as a Novel Treatment Platform for Cancer....Pages 89-105
Adenovirus Retargeting and Systemic Delivery....Pages 107-114
Front Matter....Pages 115-115
CNS Diseases Amenable to Gene Therapy....Pages 117-158
Molecular Therapies for the Nervous System and Muscle....Pages 159-178
Lentivirus: A Vector for Nervous System Applications....Pages 179-207
Front Matter....Pages 209-209
Endothelial Progenitor Cells for Neovascularization....Pages 211-216
Therapeutic Aptamers and Antidotes: A Novel Approach to Safer Drug Design....Pages 217-223
Plasmid-Based Gene Transfer and Antiprogestin-Controllable Transgene Expression....Pages 225-244
Back Matter....Pages 245-256

✦ Subjects

Cancer Research; Oncology; Neurology; Molecular Medicine; Virology

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