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Gene polymorphisms in folate metabolizing enzymes in adult acute lymphoblastic leukemia: effects on methotrexate-related toxicity and survival

✍ Scribed by Ongaro, A.; De Mattei, M.; Della Porta, M. G.; Rigolin, G.; Ambrosio, C.; Di Raimondo, F.; Pellati, A.; Masieri, F. F.; Caruso, A.; Catozzi, L.; Gemmati, D.


Book ID
126979663
Publisher
Ferrata Storti Foundation
Year
2009
Tongue
Italian
Weight
235 KB
Volume
94
Category
Article
ISSN
0390-6078

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Polymorphisms of xenobiotic metabolizing
✍ Vanessa da Silva Silveira; Renata Canalle; Carlos Alberto Scrideli; Rosane Gomes πŸ“‚ Article πŸ“… 2009 πŸ› Elsevier Science 🌐 English βš– 198 KB

The interindividual variation in the activity of xenobiotic metabolizing enzymes and DNA repair genes could modify an individual's risk of recurrent malignancy and response to therapy. We investigated whether ALL outcome was related to polymorphisms in genes CYP2D6, MPO, EPHX1, NQO1, TS, XPD and XRC