## Abstract Comparative genomic hybridization (CGH) has been widely used to detect copy number alterations in cancer and to identify regions containing candidate tumor‐responsible genes; however, gene expression changes have been described only in highly amplified regions (amplicons). To study the
Gene or genome? The meaning of gains/losses of chromosome
✍ Scribed by Fumio Itoh; Kohzoh Imai
- Publisher
- Springer Japan
- Year
- 1999
- Tongue
- English
- Weight
- 45 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0944-1174
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Comparative genomic hybridization (CGH) allows detection of chromosomal imbalances in whole genomes in a comprehensive manner. With this approach, ten cases of prostate cancer (seven primary tumors and three metastases) were analyzed. Frequent chromosomal gains detected by CGH involved chromosome ar
A series of 18 primitive neuroectodermal tumors (PNETs), the most common malignant central nervous system tumors of childhood. were analyzed with the recently developed approach of comparative genomic hybridization (CGH). In five cases, in which only small amounts of DNA were available, universal po
## Nasopharyngeal carcinoma (NPC) is a common cancer in Southern China but rare in Western countries. To search for genetic alterations in NPC, we examined a series of 20 primary tumours with comparative genomic hybridisation. The identified common chromosomal alterations included gain of chromoso
## Abstract We performed two‐color fluorescence in situ hybridization analysis to detect the numbers of chromosomes 1 and 17, 1p deletion, and 17q gain in 177 neuroblastomas, including 101 tumors that were found by a mass‐screening program for infants. Sixty‐eight tumors with disomy 1 or tetrasomy
Comparative genomic hybridization was used to screen the DNA extracted from histologically defined tissue sections from consecutive stages of colorectal carcinogenesis for chromosomal aberrations. N o aberrations were detected in normal epithelium (n = 14). Gain of chromosome 7 occurred as a single