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Gene-Gene and Gene-Environment Interactions Involving HLA-DRB1, PTPN22, and Smoking in Two Subsets of Rheumatoid Arthritis

✍ Scribed by Henrik Källberg; Leonid Padyukov; Robert M. Plenge; Johan Rönnelid; Peter K. Gregersen; Annette H.M. van der Helm-van Mil; Rene E.M. Toes; Tom W. Huizinga; Lars Klareskog; Lars Alfredsson

Book ID
117855183
Publisher
American Society of Human Genetics
Year
2007
Tongue
English
Weight
331 KB
Volume
80
Category
Article
ISSN
0002-9297

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✍ Leonid Padyukov; Camilla Silva; Patrik Stolt; Lars Alfredsson; Lars Klareskog 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 72 KB

## Abstract ## Objective The main genetic risk factor for rheumatoid arthritis (RA) is the shared epitope (SE) of HLA–DR, while smoking is an important environmental risk factor. We studied a potential gene–environment interaction between SE genes and smoking in the etiology of the 2 major subgrou