Gene Expression Profiling Predicts Therapeutic Response and Prognosis in Patients with Breast Cancer
β Scribed by G. Kesava Reddy; Joyce A. O'Shaughnessy
- Book ID
- 114412598
- Publisher
- CIG Media Group, LP.
- Year
- 2005
- Tongue
- English
- Weight
- 448 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1526-8209
No coin nor oath required. For personal study only.
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## Abstract The tumor suppressor gene __maspin__ has been reported to inhibit the invasiveness and motility of breast cancer cells. It has been reported that maspin is expressed in normal human mammary epithelial cells but is downregulated during cancer progression, and that p53 could induce maspin
## Abstract The prognostic significance of __BRCA2__ mRNA levels in tumor tissues was studied in sporadic breast cancer patients. __BRCA2__ mRNA levels were determined by realβtime PCR. Histologic grade III tumors showed significantly (__p__ = 0.001) higher __BRCA2__ mRNA levels (0.828 Β± 0.102 __BR