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Gene expression profiling for the prediction of therapeutic response to docetaxel in patients with breast cancer

โœ Scribed by Jenny C Chang; Eric C Wooten; Anna Tsimelzon; Susan G Hilsenbeck; M Carolina Gutierrez; Richard Elledge; Syed Mohsin; C Kent Osborne; Gary C Chamness; D Craig Allred; Peter O'Connell


Book ID
117284247
Publisher
The Lancet
Year
2003
Tongue
English
Weight
132 KB
Volume
362
Category
Article
ISSN
0140-6736

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## Abstract We studied the relationship between response of breast cancer to docetaxel (DOC) or cylophosphamide + epirubucin (CE) treatment and CYP3A4 mRNA expression in breast tumors. CYP3A4 inactivates DOC but not E, which is a predominant effector in CE treatment. Twenty patients with locally ad