Collagenase and stromelysin expression in recessive dystrophic epidermolysis bullosa (RDEB) was studied at both the protein and the gene expression levels in fibroblast cultures. The amount of enzyme protein in the culture medium, as determined using a specific enzyme assay, showed a 9.7-fold increa
โฆ LIBER โฆ
Gene expression of collagenase and stromelysin in skin fibroblasts derived from dystrophic epidermolysis bullosa
โ Scribed by Sugawara, Takamitsu; Nomura, Kazuo; Hashimoto, Isao
- Book ID
- 122531558
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 873 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0923-1811
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The interstitial collagenase gene (CLG), one of the main candidates in severe generalized recessive epidermolysis bullosa dystrophica (SGREBD), is closely linked to the stromelysin-1 (STMY1) and stromelysin-2 (STMY2) genes. These three loci map on chromosome 11 (q21-q22.3), where they constitute a c