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Gene expression of collagenase and stromelysin in skin fibroblasts derived from dystrophic epidermolysis bullosa

โœ Scribed by Sugawara, Takamitsu; Nomura, Kazuo; Hashimoto, Isao


Book ID
122531558
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
873 KB
Volume
6
Category
Article
ISSN
0923-1811

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Expression of collagenase and stromelysi
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Collagenase and stromelysin expression in recessive dystrophic epidermolysis bullosa (RDEB) was studied at both the protein and the gene expression levels in fibroblast cultures. The amount of enzyme protein in the culture medium, as determined using a specific enzyme assay, showed a 9.7-fold increa

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The interstitial collagenase gene (CLG), one of the main candidates in severe generalized recessive epidermolysis bullosa dystrophica (SGREBD), is closely linked to the stromelysin-1 (STMY1) and stromelysin-2 (STMY2) genes. These three loci map on chromosome 11 (q21-q22.3), where they constitute a c