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Gender-related differences in susceptibility of A/J mouse to benzo[a]pyrene-induced pulmonary and forestomach tumorigenesis

✍ Scribed by Shivendra V Singh; Patrick J Benson; Xun Hu; Ajai Pal; Hong Xia; Sanjay K Srivastava; Sanjay Awasthi; Howard A Zaren; John L Orchard; Yogesh C Awasthi

Book ID: 117469058
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 114 KB
Volume: 128
Category: Article
ISSN: 0304-3835
DOI: 10.1016/s0304-3835(98)00072-x

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## Abstract Alterations in the delicate balance between cell proliferation and cell death disrupt colon homeostasis and serve as determining factors in colon tumorigenesis. The two mouse strains, AKR/J (resistant) and A/J (susceptible), have been widely used as models for dimethylhydrazine‐induced