Gefitinib (‘Iressa’), an epidermal growth factor receptor tyrosine kinase inhibitor, mediates the inhibition of lymph node metastasis in oral cancer cells
✍ Scribed by Satoru Shintani; Chunnan Li; Mariko Mihara; Koh-ichi Nakashiro; Hiroyuki Hamakawa
- Book ID
- 117467952
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 239 KB
- Volume
- 201
- Category
- Article
- ISSN
- 0304-3835
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## Abstract Progression from an androgen‐dependent to an androgen‐independent state often occurs in patients with prostate cancer (PCa) who undergo hormonal therapy. We have investigated whether inhibition of the epidermal growth factor receptor (EGFR) signaling pathway affects the antitumor effect
## Abstract The epidermal growth factor (EGF) plays a role in the development of prostate cancer, which becomes essential after androgen resistance has emerged. The EGF receptor (EGFR) is therefore a potential target for anticancer therapy. We evaluated the effects of ZD1839 (‘Iressa’), an orally a