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Gefitinib (‘Iressa’, ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, up-regulates p27KIP1 and induces G1 arrest in oral squamous cell carcinoma cell lines

✍ Scribed by Satoru Shintani; Chunnan Li; Mariko Mihara; Junya Yano; Nagaaki Terakado; Koh-ichi Nakashiro; Hiroyuki Hamakawa

Book ID
114394044
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
508 KB
Volume
40
Category
Article
ISSN
1368-8375

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✍ Elena Di Gennaro; Marcella Barbarino; Francesca Bruzzese; Sonya De Lorenzo; Mich 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 348 KB 👁 1 views

## Abstract High expression of the epidermal growth factor receptor (EGFR) has been implicated in the development of squamous‐cell carcinomas of head and neck (SCCHN). ZD1839 (‘Iressa’) is an orally active, selective EGFR‐TKI (EGFR‐tyrosine kinase inhibitor) that blocks signal transduction pathways