Gd-DOTA as a gastrointestinal contrast agent for gastric emptying measurements with MRI

✍ Scribed by W. Schwizer; R. Fraser; H. Maecke; K. Siebold; R. Funck; M. Fried

• Book ID: 102955871
• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: English
• Weight: 665 KB
• Volume: 31
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.1910310407

✦ Synopsis

Abstract

Current MR meal markers may interfere with gastric motility and secretion restricting the use of MRI in the measurement of gastric physiology. We therefore evaluated Gd‐DOTA as a liquid phase marker, in vitro by determining dissociation, and adherence to the solids, and in vivo by simultaneous MRI (0.35 T scanner, multiple T~1~‐weighted sections of the upper abdomen) and double indicator (perfusion marker PEG 4000, meal marker ^99m^Tc‐DTPA) measurements of emptying and secretion, following ingestion of 500 ml 10% glucose. In vitro Gd‐DOTA was stable at a pH > 2 with < 2% dissociation at 24 h during incubation with HCI. Dissociation during incubation with HCI was linearly dependent on H^+^ concentration (0.77 < pH < 2.02). Less Gd‐DOTA was absorbed onto the solid phase than ^99m^Tc‐DTPA (25% cf 36%). in vivo Gd‐DOTA marked gastric contents provided strong positive contrast. Similar emptying curves were observed with both MRI and double‐indicator techniques (r = 0.987, P < 0.001). Gd‐DOTA has the potential to be a useful liquid phase contrast agent in MR studies on gastric function.