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Gas-liquid chromatographic determination of moprolol (SD 1601) in human plasma and urine

✍ Scribed by Desager, J. P.

Publisher
John Wiley and Sons
Year
1980
Tongue
English
Weight
326 KB
Volume
3
Category
Article
ISSN
0935-6304

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✦ Synopsis

Abstract

1‐(o‐methoxyphenoxy)‐3‐isopropylamino‐2‐propanol hydrochloride (moprolol, Omeral^R^), is a new β‐adrenergic blocking agent. A gas chromatographic method for determining unchanged moprolol in human biological fluids has been developed. After solvent extraction, a bis‐trifluoroacetyl derivative was formed and measured by an electron capture detector. The quantification was checked by using an internal standard (pronethalol), which was added to all samples. The electron capture response was linear between 10 and 500 ng/ml. To avoid contamination of the peaks, careful extraction was imperative. The main advantages offered by the described method are: specificity, high sensitivity (10 ng.ml^βˆ’1^) and the small amount of biological fluids (1 ml plasma a. e.) required.

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