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Gas chromatography—mass spectrometry characteristics of methylated perfluoroacyl derivatives of cytosine and 5-methylcytosine

✍ Scribed by G.B. Mohamed; A. Nazareth; M.J. Hayes; R.W. Giese; Paul Vouros

Book ID
104146668
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
439 KB
Volume
314
Category
Article
ISSN
1873-3778

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✦ Synopsis

Pentafluorobenzoyl and heptafluorobutyryl derivatives of cytosine and pentafluorobenzoyl-5methylcytosine have been examined by mass spectrometry following permethylation. Electron impact mass spectra were used to confirm the structures of the derivatives. The permethylated pentafluorobenzoyl derivatives of cystosine and 5-methylcytosine are sensitive for quantitative analysis by capillary gas chromatography-mass spectrometry. Under negative ion chemical ionization conditions 1 femtogram of each is detected.

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