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Analysis of modified bases in DNA by stable isotope dilution gas chromatography-mass spectrometry: 5-Methylcytosine

✍ Scribed by Pamela F. Crain; James A. McCloskey

Publisher: Elsevier Science
Year: 1983
Tongue: English
Weight: 733 KB
Volume: 132
Category: Article
ISSN: 0003-2697
DOI: 10.1016/0003-2697(83)90434-7

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## Abstract __N__‐acetylaspartic acid (NAA) is a specific urinary marker for Canavan disease, an autosomal recessive leukodystrophy. We developed a ‘dilute and shoot’ stable isotope dilution liquid chromatography tandem mass spectrometry (LC‐MS/MS) method for determination of NAA in urine. Deuterat