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Gas chromatographic method for the determination of dextropropoxyphene and nordextropropoxyphene in human plasma, serum and urine

✍ Scribed by Helle Riis Angelo; Jytte Molin Christensen

Publisher
Elsevier Science
Year
1977
Tongue
English
Weight
263 KB
Volume
140
Category
Article
ISSN
1873-3778

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✦ Synopsis

Cases of acute poisoning by overdosing of dextropropoxyphene, which is awidely used analgesic, have appeared with growing frequency during the past few years. A method for the .relatively rapid determination of dextropropoxyphene and its major metabolite nordextropropoxyphene is thus required. Previously described gas chromatographic (GC) methods1-3 are based on determining dextropropoxyphene and nordextropropoxyphene (Fi g. 1) without derivatization, and great problems with on-column decomposition have been describedJd.

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