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A gas-liquid chromatographic method for the quantitative determination of methadone in human plasma and urine.

✍ Scribed by Charles E. Inturrisi; Karl Verebely

Publisher
Elsevier Science
Year
1972
Tongue
English
Weight
824 KB
Volume
65
Category
Article
ISSN
1873-3778

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✦ Synopsis

A method employing solvent extraction and. gas-liquid chromatography is described which can detect as little as 0,015 ,ug of methadone per ml of human plasma. The method has been used to determine the concentration of methadone in plasma samples from normal volunteers given a single dose of methadone, from cancer patients receiving multiple doses for pathological pain and' from former heroin addicts in a methadone treatment program. The concentration of methadone and its two metabolites in the urine of normal volunteers has also been determined.

Pollowing the intramuscular administration of 10 mg of methadone to three normal volunteers the drug disappeared from plasma with an average biologic half-, life of 7.3 h.

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