New chiral stationary phases of polydimethylsiloxane anchored with (S)-(Γ)-t-leucine derivatives were provided for use in enantiomer separation of pharmaceuticals by capillary gas chromatography. Fifteen pharmaceuticals were separated into their enantiomeric pairs by converting them into pentafluoro
Gas chromatographic enantiomer separation of pharmaceuticals on capillary columns coated with novel chiral polysiloxanes
β Scribed by Iwao Abe; Takako Nishiyama; Taketoshi Nakahara; Hartmut Frank
- Book ID
- 107785163
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 421 KB
- Volume
- 694
- Category
- Article
- ISSN
- 1873-3778
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## Abstract The influence of different polysiloxane solvents on the efficiency and stereoselectivity of columns coated with mixtures of heptakis(2,3βdiβOβmethylβ6βOβ__tert__βbutyldimethylsilyl)βΞ²βcyclodextrin (DIMEβ6βTBDMSβΞ²βCD) and the polysiloxanes was investigated. In the case of DIMEβ6βTBDMSβΞ²β
The applicability of permethylated P-cyclodextrin as an enantioselective stationary phase for capillary gas chromatography has been investigated. Attention has been paid to its phase transitions in a temperature range of 40-2OO0C. The enantiomer separation of 2-substituted propionates and some lower