Gangliosides GM1 and GD1b are not polarized in mature hippocampal neurons
β Scribed by Hidehiko Shogomori; Michelle A Burack; Gary Banker; Anthony H Futerman
- Book ID
- 117111401
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 580 KB
- Volume
- 458
- Category
- Article
- ISSN
- 0014-5793
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We have studied the cellular distribution of gangliosides GD1b, GD3 and GM1 in rat cerebellum by immunostaining, using monoclonal antibodies and confocal microscopy. Antibodies against astroglial, neuronal and synaptic vesicle associated molecules were used for colocalization analyses. In the gray m
Fifty-nine percent of 49 patients with motor neuron disease and 25% of 91 control subjects had IgM antibodies to ganglioside GM1 but usually not to GDlb at titers less than 1:80. This suggests that antibodies to GM1 may be part of the normal human antibody repertoire. However, given the higher incid