𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Gamma-secretase activating protein is a therapeutic target for Alzheimer’s disease

✍ Scribed by He, Gen; Luo, Wenjie; Li, Peng; Remmers, Christine; Netzer, William J.; Hendrick, Joseph; Bettayeb, Karima; Flajolet, Marc; Gorelick, Fred; Wennogle, Lawrence P.

Book ID
109899120
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
497 KB
Volume
467
Category
Article
ISSN
0028-0836

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Cdk5, a therapeutic target for Alzheimer
Cdk5, a therapeutic target for Alzheimer's disease?
✍ Li-Huei Tsai; Ming-Sum Lee; Jonathan Cruz 📂 Article 📅 2004 🏛 Elsevier Science 🌐 English ⚖ 124 KB

Alzheimer's disease (AD) represents the leading cause for senile dementia affecting more than 4 million people worldwide. AD patients display a triad of pathological features including brain atrophy caused by neuronal loss, h-amyloid plaque and neurofibrillary tangles. We previously show that Cyclin

β-secretase as a target for the treatmen
β-secretase as a target for the treatment of Alzheimer's disease
✍ Martin Citron 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 490 KB 👁 1 views

## Abstract Finding inhibitors of the first step of the amyloid cascade, Aβ~42~ generation, is a major goal of Alzheimer's disease drug development. Two target protease activities, β‐and γ‐secretase, were detected more than 10 years ago but progress in this area has been slow because the enzymes we